Advances in spinal fusion: molecular science, biomechanics, by Kai-Uwe Lewandrowski

By Kai-Uwe Lewandrowski

Showcasing rising study and know-how within the box, Lewandrowski (fellow, spinal surgical procedure, Cleveland sanatorium) offers descriptions of a brand new iteration of fabrics and units able to particular organic interactions to augment spinal fusion, from biodegradable implants and advances in drug supply to recombinant DNA options, bioreactors, stem mobile isolation, and 2nd and 3D scaffolds for cells. The e-book bargains with matters within the number of right biomaterials that deal with biocompatibility and biostability, particular biomaterials and their physiochemical and mechanical characterizations. matters with regards to criteria in analytical technique and quality controls also are mentioned. participants come from fields starting from the fundamental sciences, corresponding to polymer chemistry, to extra utilized disciplines, akin to chemical engineering, orthopedics, and pharmaceutics. B&w drawings and clinical photos are incorporated.

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Several factors contribute to the mechanical stabilization achieved by PV, including the density of the VB, the volume and location of the cement injected, and the material properties of the cement. The optimal cement volume and material properties have not yet been determined. III. MECHANICAL CONSIDERATIONS How much cement is needed to stabilize VCFs has been a clinical concern since the onset of PV practice. A recent ex vivo study reported that only 2 mL of PMMA were needed to restore strength in osteoporotic VBs, but that larger volumes (4–6 mL) were needed to restore stiffness [43].

Radiol. Clin. North Am 1998; 36:533–546. 26. Silverman SL. The clinical consequences of vertebral compression fracture. Bone 1992; 13:S27–S31. 27. Gennari C, Agnusdei D, Camporeale A. Use of calcitonin in the treatment of bone pain associated with osteoporosis. Calcif. Tissue Int 1991; 49:S9–S13. 28. Antonacci MD, Mody DR, Heggeness MH. Innervation of the human vertebral body: a histologic study. J. Spinal Disord 1998; 11:526–531. 29. Jefferiss CD, Lee AJC, Ling RSM. Thermal aspects of self-curing polymethylmethacrylate.

Other causes of back pain, such as sacral insufficiency fractures, must be ruled out by a complete history and physical examination. Once this has been established, the next challenge is determining the symptomatic level. By percussing the midline of the spine, the most tender level is determined. This can then be marked by a radiopaque marker, such as paper clip, prior to obtaining radiographs. Also, the examiner can attempt to identify the number of the spinous process. Plain radiographs are useful in assessing overall spinal balance.

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